药用活性化合物（PHAC）在水生生物中广泛存在 环境正在引起全世界对水生生物潜在不利影响的担忧 生态与人类健康。高锰酸钾（KMnO₄），一种强有力的 目前公用事业公司用于解决一系列问题的环保氧化剂是 对PHAC的氧化去除可能有效。这项研究是首次报道 KMnO₄水处理过程中广泛检测到的PHAC氧化的时间。 18种化学品，涵盖几个主要类别的药品和 对废水产生的微污染物进行了筛选，以确定其与 高锰酸盐。 结果表明，筛选出的PHAC中有10个是高度或中度PHAC 与KMnO₄反应。然后对反应性最强的催化剂进行了详细的动力学研究 PHAC（卡马西平氧化的结果在本文中详细描述）到 确定基本动力学参数，并评估重要水质的影响 参数（pH、温度）和非目标水成分（如天然有机物（NOM））的存在， Fe²⁺、Mn²⁺等）。两种公用水源水中卡马西平的去除效率 用KMnO₄处理后也进行了测试，结果与预测相当吻合 根据在去离子水中进行的实验参数化的动力学模型 试剂浓度要高得多。研究了几种卡马西平氧化产物 经液相色谱-串联质谱鉴定，并提出了结构 对于这些中间体，证实了一种氧化机制，涉及在 卡马西平中心杂环中的非芳香烯基。包括19个参考文献、表格和图表。

The widespread occurrence of pharmaceutically active compounds (PhACs) in aquatic environment is raising worldwide concerns about potential adverse effects on aquatic ecology and human health. Potassium permanganate (KMnO₄), a powerful and environmentally friendly oxidant currently used by utilities to address a range of issues, is potentially effective for oxidative removal of PhACs. This study reports for the first time on the oxidation of widely detected PhACs during water treatment with KMnO₄. Eighteen chemicals, covering several major classes of pharmaceuticals and wastewater-derived micropollutants, were screened for potential reactivity with permanganate. Results show that ten of the screened PhACs are either highly or moderately reactive with KMnO₄. Detailed kinetic studies were then performed for the most reactive PhACs (results from carbamazepine oxidation are described in detail in this paper) to determine basic kinetic parameters and evaluate the effects of important water quality parameters (pH, temperature) and the presence of non-target water constituents (e.g., natural organic matter (NOM), Fe²⁺, Mn²⁺, and etc.). The removal efficiency of carbamazepine in two utility source waters treated with KMnO₄ was also tested and the results agree reasonably well with predictions from the kinetic model parameterized using experiments conducted in deionized water at much higher reagent concentrations. Several carbamazepine oxidation products were identified by liquid chromatography-tandem mass spectrometry, and the proposed structures for these intermediates confirmed an oxidation mechanism involving electrophilic attack at the non-aromatic olefinic group in the central heterocyclic ring of carbamazepine. Includes 19 references, tables, figures.