本文描述了一种微固相萃取方法，该方法已被开发和验证，可用于180多种化合物的定量分析，包括农药、除草剂、各种己二酸和邻苯二甲酸盐、多环芳烃（PAHs）和多氯联苯（PCBs）。该方法只需要20毫升样品，用7毫米C18磁盘盒提取。浓缩提取物，并将25微升直接注入配备大容量注入器的气相色谱仪/质谱仪。通过优化固相萃取和仪器操作条件，发现该方法的检测限在亚ppb范围内。验证数据表明，大量分析物可以有效地从C18磁盘盒中洗脱，从而产生与EPA方法525类似的灵敏度。 2.微固相萃取非常具有成本效益，因为它允许收集小体积的样品，并且使用更少的溶剂。这种方法也符合EPA简化方法的努力，并为小型水系统提供了价格合理的杀虫剂筛选。

This paper describes a micro-solid phase extraction method that has been developed and validated for the quantitative analysis of over 180 compounds including pesticides, herbicides, various adipates and phthalates, polynuclear aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs). The method requires only 20 mL of sample which is extracted with a 7 mm C18 disk cartridge. The extract is concentrated and 25 uL is injected directly into a gas chromatograph/mass spectrometer equipped with a large volume injector. By optimizing the solid phase extraction and instrument operational conditions, the detection limits with this method were found to be in the sub-ppb range. Validation data indicated that a large number of analytes can be effectively eluted from the C18 disk cartridge resulting in sensitivity similar to EPA method 525.2. The micro-solid phase extraction is very cost effective as it allows for the collection of small sample volumes and uses less solvent. This method is also in line with EPA's effort to streamline methodology and provides an affordable pesticide screen for small water systems.