1.1 本试验方法包括测定从工作场所和周围大气中采集的空气样品中的气溶胶六亚甲基二异氰酸酯（HDI）。本试验方法中描述的方法收集单独的部分。一部分将由蒸汽控制，另一部分将由气溶胶控制。从单独部分的分析中获得的结果不一定代表测量的HDI物理相的真实分配，而应仅被视为代表样本内物理相分配的一般趋势。这两个分数的分析是不同的，以单独、链接的标准提供，以避免混淆。本试验方法主要用于确定在工作场所环境中进行个人监测或在环境空气中的短期HDI暴露（15分钟）。 如试验方法所述，单独进行蒸汽分数分析 D6562 . 1.2 差分空气采样使用分离装置进行。气溶胶部分收集在聚四氟乙烯（PTFE）过滤器上。 1.3 使用配备紫外线（UV）检测器的高效液相色谱仪（HPLC）对气溶胶部分进行分析。也可以使用超高效液相色谱仪（UPLC），前提是其性能等同于本标准中的规定。试验方法的应用范围已从0.052至1.04μg单体HDI/mL进行验证，基于15 L空气样品，其对应于0.052至1.04μg单体HDI/mL的浓度。 004至0.070 mg/m 3. 人类发展指数。这些浓度对应于从0.5 ppb（V）到10 ppb（V）的气溶胶相浓度范围，并覆盖5 ppb（V）的既定阈值限制阀（TLV）。 1.4 单体HDI的定量限为0.041μg/mL，相当于0.003 mg/m 3. 对于15 L采样风量。该值相当于在与浓度为0.1μg/mL接近预期检测限的PTFE过滤器接触的标准溶液上进行十次测量所得标准偏差的十倍。 1.5 以国际单位制表示的数值应视为标准值。本标准不包括其他计量单位。 1.6 本标准并非旨在解决与其使用相关的所有安全问题（如有）。 本标准的用户有责任在使用前制定适当的安全、健康和环境实践，并确定监管限制的适用性。 参见第节 9 其他危险。 1.7 本国际标准是根据世界贸易组织技术性贸易壁垒（TBT）委员会发布的《关于制定国际标准、指南和建议的原则的决定》中确立的国际公认标准化原则制定的。 ====意义和用途====== 5.1 HDI主要用于涂料的制备。异氰酸酯的使用及其工业需求一直在不断增长。 5. 2. 二异氰酸酯和多异氰酸酯对皮肤、眼睛和粘膜有刺激性。它们被认为会引起呼吸道过敏性致敏、哮喘性支气管炎和急性呼吸道中毒 ( 3- 6. ) . 5.3 美国政府工业卫生学家会议（ACGIH）采用了0.005 ppm（V）或0.034 mg/m的阈值-时间加权平均值（TLV-TWA） 3. 对于单体HDI ( 7. ) . 美国劳工部职业安全与健康管理局（OSHA）尚未列出人类发展指数的允许接触限值（PEL） ( 8. ) . 5.4 无论如何，对于蒸汽和气溶胶没有单独的暴露标准。因此，在将异氰酸酯的结果与标准品进行比较时，应将两种馏分的结果结合起来，得出一个总值。 5.5 由于其低LOD和低所需体积（15 L），该试验方法非常适合监测与二异氰酸酯和多异氰酸酯相关的呼吸和其他问题。其采样时间短，与许多工业过程的持续时间相适应，其低检测限与工作区域中经常发现的浓度相适应。

1.1 This test method covers the determination of aerosol hexamethylene diisocyanate (HDI) in air samples collected from workplace and ambient atmospheres. The method described in this test method collects separate fractions. One fraction will be dominated by vapor, and the other fraction will be dominated by aerosol. The results obtained from the analysis of the separate fractions do not necessarily represent the true partition of the measured HDI physical phases, and should only be considered a representation of the general trend in the physical phase partition within samples. The analyses of the two fractions are different, and are provided in separate, linked, standards to avoid confusion. This test method is principally used to determine short term exposure (15 min) of HDI in workplace environments for personal monitoring or in ambient air. The analysis of the vapor fraction is performed separately, as described in Test Method D6562 . 1.2 Differential air sampling is performed with a segregating device. The aerosol fraction is collected on a polytetrafluoroethylene (PTFE) filter. 1.3 The analysis of the aerosol fraction is performed by using a high performance liquid chromatograph (HPLC) equipped with an ultraviolet (UV) detector. An ultra high performance liquid chromatograph (UPLC) can also be used, provided that its performance is equivalent to what is stated in this standard. The range of application of the test method has been validated from 0.052 to 1.04 μg of monomeric HDI/mL, which corresponds, based on a 15 L air sample, to concentrations from 0.004 to 0.070 mg/m 3 of HDI. Those concentrations correspond to a range of aerosol phase concentrations from 0.5 ppb (V) to 10 ppb (V) and cover the established threshold limit valve (TLV) value of 5 ppb (V). 1.4 The quantification limit for the monomeric HDI is 0.041 μg per mL, which corresponds to 0.003 mg/m 3 for a 15 L sampled air volume. This value is equivalent to ten times the standard deviation obtained from ten measurements carried out on a standard solution in contact with the PTFE filter whose concentration of 0.1 μg/mL is close to the expected detection limit. 1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.6 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. See Section 9 for additional hazards. 1.7 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee. ====== Significance And Use ====== 5.1 HDI is mostly used in the preparation of paints. The use of isocyanates and their industrial needs have been in constant growth. 5.2 Diisocyanates and polyisocyanates are irritants to skin, eyes, and mucous membranes. They are recognized to cause respiratory allergic sensitization, asthmatic bronchitis, and acute respiratory intoxication ( 3- 6 ) . 5.3 The American Conference of Governmental Industrial Hygienists (ACGIH) has adopted a threshold limit value–time weighted average (TLV-TWA) of 0.005 ppm (V) or 0.034 mg/m 3 for monomeric HDI ( 7 ) . The Occupational Safety & Health Administration of the U.S. Department of Labor (OSHA) has not listed a permissible exposure limit (PEL) for HDI ( 8 ) . 5.4 In any case, there are not separate exposure standards for vapor and aerosol. Therefore, in comparing the results for isocyanate against a standard, results from the two fractions should be combined to give a single total value. 5.5 Due to its low LOD and low required volume (15 L), this test method is well suited for monitoring of respiratory and other problems related to diisocyanates and polyisocyanates. Its short sampling times are compatible with the duration of many industrial processes, and its low detection limit with the concentrations often found in the working area.