本幻灯片概述了新兴饮用水消毒副产品（DBP）对哺乳动物细胞毒性的研究。研究目标包括:美国环境保护局（USEPA）提供约50 mg合成， 分析级DBP； 分析直接作用的细胞毒性和基因组结构 中国人DBPs个体的遗传毒性 仓鼠卵巢（CHO）细胞； 确定细胞毒性和基因毒性的等级顺序 DBP；和 建立DBP毒性的定量和比较模型 数据库概述的主题包括:发展定量研究的障碍 和比较DBP毒性数据库；32年后，DBP仍然被考虑 新出现的污染物；解决一个企业面临的障碍 DBPs的比较毒理学；美国环境保护局的研究题为“饮用水中健康问题的消毒副产物（DBPs）的发生: 美国环境保护局第2阶段DBP规则；氯消毒替代品；新兴DBP化学品类别 目前正在分析的；中国仓鼠卵巢细胞；哺乳动物细胞慢性病 细胞毒性试验；细胞毒性吸收数据: 二溴乙酰胺；CHO细胞毒性 卤乙酸， 新兴的卤代酸DBP、卤代硝基甲烷；使用以下方法分析的DBP摘要 CHO慢性细胞毒性试验；饮酒引起的基因组DNA损伤 水消毒副产物；单细胞凝胶电泳分析 卤乙酸，新兴的卤酸， CHO细胞中的卤代硝基甲烷；比较DBP基因毒性数据库。包括数字。

This slide presentation outlines a study on mammalian cell toxicity of emerging drinking water disinfection byproducts (DBP). Objectives of the study include: U.S. Environmental Protection Agency (USEPA) provides ~50 mg samples of synthesized, analytical grade DBP; analyze the direct-acting cytotoxicity and genomic genotoxicity of the individual DBPs with Chinese hamster ovary (CHO) cells; determine the cytotoxic and genotoxic rank order of the DBPs; and, develop a quantitative and comparative DBP toxicity database. Topics outlined include: Impediments to the Development of a Quantitative and Comparative DBP Toxicity Database; after 32 years, DBPs are still considered emerging contaminants; Solutions to the Impediments for a Comparative Toxicology of DBPs; USEPA study titled, "The Occurrence of Disinfection Byproducts (DBPs) of Health Concern in Drinking Water: Results of a Nationwide DBP Study Occurrence Study"; USEPA Stage 2 DBP Rule; alternatives to chlorine disinfection; Emerging DBP Chemical Classes That Are Currently Being Analyzed; Chinese Hamster Ovary Cells; Mammalian Cell Chronic Cytotoxicity Assay; Cytotoxicity Absorbancy Data: Dibromoacetamide; CHO Cell Cytotoxicity of Haloacetic Acids, Emerging Haloacid DBPs, Halonitromethanes; Summary of DBPs Analyzed with the CHO Chronic Cytotoxicity Assay; Genomic DNA Damage Induced by Drinking Water Disinfection Byproducts; SCGE Analysis of Haloacetic Acids, emerging Haloacids, Halonitromethanes in CHO Cells; and, Comparative DBP Genotoxicity Database. Includes figures.