将雄性和雌性B6C3F1小鼠分为两组，在饮用水中连续90天给予氯气和一氯胺。两种消毒剂的供应量分别为12.5、25、50、100和200 mg/L。评估标准包括死亡率、临床症状、体重、食物消耗量、血液学、临床化学、器官重量、大体病理学和组织病理学。总的来说，在缺乏组织病理学和可观察到的毒性临床症状的情况下，生化、血液学和器官重量数据的相关性表明，氯和一氯胺通过一种间接机制，即e。 g、 ，而不是对特定器官或组织的直接毒理学影响。包括32个参考文献和表格。

Separate groups of male and female B6C3F1 mice were administered chlorine and monochloramine in drinking water for 90 consecutive days. Both disinfectants were supplied at 12.5, 25, 50, 100 and 200 mg/L. Criteria evaluated included mortality, clinical signs, body weight, food consumption, hematology, clinical chemistry, organ weights, gross pathology, and histopathology. Overall, the correlation of the biochemical, hematological, and organ weight data, in the absence of histopathology and observable clinical signs of toxicity, suggests that the chlorine and monochloramine induced effects via an indirect mechanism, e.g., nutritional deficiencies, rather than a direct toxicological effect on specific organs or tissues. Includes 32 references, tables.