减少医院手术室空气传播细菌感染的一个可能因素是减少空气从非无菌区进入无菌区。开发了虚拟医院手术室的计算流体动力学（CFD）模型，以分析送风量或ACH对气流模式、温度分布以及产生的空气颗粒流路径的影响。这些分析表明，供给气流速率，以及单向空气射流的排放速度，对整体气流模式的影响很小，并且在所有供给气流速率水平下，非无菌区内都会发生热分层。增加送风量和送风的相关热容量有助于减少无菌和非无菌空气之间的热梯度- 无菌区，从而减少空气从非无菌区进入无菌区。增加送风量也可以显著降低中心线速度的相对加速度，这表明夹带减少。这项研究进一步表明，送风量对空气颗粒物的整体流动路径影响不大。当这些颗粒物起源于无菌区时，它们通常会被扫到非无菌区，在离开手术室之前，它们可以在那里再循环，而不会出现明显的二次夹带。然而，当这些颗粒物来自非无菌区时，无论供应气流速度如何，它们都会被带入无菌区。 可能需要改变这些颗粒的流动路径，以避免此类夹带。这只能通过显著改变非无菌区的气流模式来实现。医院手术室的传统暖通空调设计涉及层流送风扩散器的天花板阵列和对面墙上的低墙排气格栅，可能需要进一步评估。引文:2017年冬季会议，内华达州拉斯维加斯，会议论文

A probable factor in minimizing the infection due to airborne bacteria in the hospital operating room is to minimize the entrainment of air from the non-sterile zone into the sterile zone. A Computational Fluid Dynamics (CFD) model of a virtual hospital operating room is developed to analyze the impact of supply airflow rates or ACH on the airflow patterns, temperature distribution, and on the resulting flow path of airborne particulates. These analyses indicate the supply airflow rate, and hence, the discharge velocity of the unidirectional air jet, has a little impact on the overall airflow patterns and the thermal stratification in non-sterile zone occurs at all levels of supply airflow rates. Increasing the supply airflow rate and associated heat capacity of the supply air helps in reducing thermal gradients between the sterile and non-sterile zones which in turn may reduce the entrainment of the air from the non-sterile zone into the sterile zone. Increasing the supply airflow rate can also significantly reduce relative acceleration of the centerline velocity – an indication of the reduction in the entrainment. This study further indicates the supply airflow rate has a little impact on the overall flow path of airborne particulates. When these particulates are originated within a sterile zone they are generally swept away into the non-sterile zone where they can recirculate without significant re-entrainment before exiting the operating room. However, when these particulates originate from the non-sterile zone, irrespective of the supply airflow rate, they get entrained into the sterile zone. The flow of path of these particulates may need to be altered in order to avoid such entrainment. This can be achieved only by significantly altering the airflow patterns in the non-sterile zone. The legacy HVAC design for hospital operating rooms involving a ceiling array of laminar supply diffusers and low wall exhaust grills on the opposite walls may require further evaluation.