This publication alerts carbon dioxide producers and plant operators to potential risks related to changing carbon dioxide feed gas composition. It also discusses the dangers related to excess oxygen or hydrocarbon levels in catalytic oxidation and sulfur and hydrocarbon removal systems used to purify carbon dioxide. In addition, potential fire hazards that can be encountered when spent adsorbent media is exposed to air during periodic replacement are reviewed. Finally, this publication provides recommendations to prevent fire and explosions related to these causes in by-product carbon dioxide plants.