The energy use-related effects of ultraviolet germicidal irradiation (UVGI) to mitigate biological fouling (biofouling) of a chilled water cooling coil areinvestigated via a field study. A visibly bio-fouled cooling coil in an air-handling unit serving an operational building in a hot, humid climate is monitoredfor 5 months to establish a fouled coil baseline. Parameters monitored include air flow rate, airside pressure drop, air temperature and humidity upstreamand downstream of the coil, chilled water flow rate, entering and leaving chilled water temperature, and waterside pressure drop. A UVGI coilirradiation system is installed on the downstream side of the coil following typical manufacturer guidelines, and the system is then passively monitored overa period of 14 months. The change in operation is estimated by comparing data from the baseline and post-irradiation periods. The 95% confidenceintervals for average improvement of coil airside pressure drop and heat transfer coefficient are 11.07% to 11.13%, and 14.5% to 14.6%, respectively.Complexities of the physical phenomena involved, in particular, the combined effect of airflow and latent load on airside pressure drop, are taken intoaccount.