1.1本指南涉及使用纳米粒子跟踪分析（NTA）技术测量悬浮颗粒的粒径分布，从约10 nm到沉降开始，取决于样品。它没有提供任何特定纳米材料的完整测量方法，但提供了良好实践应遵循的方法的一般概述和指南，以及潜在的陷阱。 1.2以国际单位制表示的数值应视为标准值。本标准不包括其他计量单位。 1.3 本标准并非旨在解决与其使用相关的所有安全问题（如有）。本标准的用户有责任在使用前制定适当的安全和健康实践，并确定监管限制的适用性。 ====意义和用途====== NTA是为数不多的能够测量纳米尺寸区域内粒度分布的技术之一。本指南描述了直接可视化和测量布朗运动的NTA技术，该技术通常适用于从几纳米到样品中开始沉淀的粒径范围。NTA技术通常用于稀释液体载体中固体材料的悬浮液。这是一种第一原理方法（即校准在标准理解这个词时，不涉及）。测量基于流体动力学，因此提供悬浮介质（通常为水）中的尺寸信息。因此，流体动力学直径几乎肯定会与其他技术确定的粒径不同，NTA技术的用户在进行技术比较之前需要了解粒径各种描述符的区别（见8）。 7). 尽管有上述规定，该技术在工业界和学术界通常被用作研究和开发工具以及亚微米系统表征的质量控制方法。

1.1 This guide deals with the measurement of particle size distribution of suspended particles, from ~10 nm to the onset of sedimentation, sample dependent, using the nanoparticle tracking analysis (NTA) technique. It does not provide a complete measurement methodology for any specific nanomaterial, but provides a general overview and guide as to the methodology that should be followed for good practice, along with potential pitfalls. 1.2 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. ====== Significance And Use ====== NTA is one of the very few techniques that are able to deal with the measurement of particle size distribution in the nano-size region. This Guide describes the NTA technique for direct visualization and measurement of Brownian motion, generally applicable in the particle size range from several nanometers until the onset of sedimentation in the sample. The NTA technique is usually applied to dilute suspensions of solid material in a liquid carrier. It is a first principles method (that is, calibration in the standard understanding of this word, is not involved). The measurement is hydrodynamically based and therefore provides size information in the suspending medium (typically water). Thus the hydrodynamic diameter will almost certainly differ from size diameters determined by other techniques and users of the NTA technique need to be aware of the distinction of the various descriptors of particle diameter before making comparisons between techniques (see 8.7). Notwithstanding the preceding sentence, the technique is routinely applied in industry and academia as both a research and development tool and as a QC method for the characterization of submicron systems.