In several situations, simultaneous needs in heating and cooling in buildings can occur. A heat pump for simultaneous heating and coolingcan be installed advantageously in this kind of buildings. Unlike a reversible heat pump that works either in heating or cooling, a heat pump forsimultaneous heating and cooling has the distinction of operating under three modes: heating mode, cooling mode and simultaneous mode.In this article, different types of buildings are considered and simulated using TRNSYS software to identify the needs for heating, coolingand domestic hot water production (DHW). The introduction of a ratio of simultaneous heating and cooling needs (RSN) can qualify buildingsin relation to the appropriateness of a simultaneous production technology. Three kinds of buildings are investigated (Low-Energy Building, officebuilding and retail space) in different climates (Rennes, Marseille, and Strasbourg).As the design of a heat pump is highly dependent on the properties of the refrigerant, models of small heat pumps for simultaneous heatingand cooling using R290 and HFO1234yf are developed. Results of experimental tests on a 15 kW-51182.1 Btu/h heating capacity heat pumpfor simultaneous heating and cooling working with R407C were used to validate the numerical models of refrigeration components. Finally, a cosolvingtechnique using two environments (EES and TRNSYS) is used to compare the performance of the different refrigerants coupled to thebuilding with best RSN.