ISO 17853:2011规定了人体和关节模拟器中关节置换植入物产生的磨损颗粒取样方法。它规定了仪器、试剂和测试方法，用于从从关节置换植入物周围切除的组织样本、翻修手术或验尸时获得的组织样本以及关节模拟器测试液样本中分离和表征聚合物和金属磨损颗粒。其中一些程序当然可以适用于从人体生物液（例如滑液）中分离和表征颗粒。

ISO 17853:2011 specifies methods for sampling wear particles generated by joint replacement implants in humans and in joint simulators. It specifies the apparatus, reagents and test methods to isolate and characterize both polymer and metal wear particles from samples of tissues excised from around the joint replacement implant, obtained at revision surgery or post mortem, and from samples of joint simulator test fluids. Some of these procedures could certainly be adapted for isolation and characterization of particles from human biological fluids (e.g. synovial fluid).