本文件确定了作为综合测量系统一部分的参数和条件，这些参数和条件是开发和验证非对称流和离心场流分馏方法应用于分析纳米物体及其分散在水介质中的聚集体和团聚体所必需的。除了组分分馏外，分析还可以包括粒度、粒度分布、浓度和使用一个或多个合适检测器的材料识别。为应用提供了一般指南和程序，并规定了再现方法和传达关键方面所需的最低报告要求。

This document identifies parameters and conditions, as part of an integrated measurement system, necessary to develop and validate methods for the application of asymmetrical-flow and centrifugal field-flow fractionation to the analysis of nano-objects and their aggregates and agglomerates dispersed in aqueous media. In addition to constituent fractionation, analysis can include size, size distribution, concentration and material identification using one or more suitable detectors. General guidelines and procedures are provided for application, and minimal reporting requirements necessary to reproduce a method and to convey critical aspects are specified.