在单独的亚慢性毒性研究中，雄性和雌性SpragueDawley大鼠在其饮用水中连续90天接受不同剂量的氯、一氯胺或二氧化氯。在使用的任何浓度下，消毒剂都不会导致过早死亡。经检测，氯的最高剂量（250 mg/L）为未观察到的不良反应水平。在200 mg/L（可观察到的最低不良反应水平）时，一氯胺会使两性的体重和器官重量降低，男性的红细胞计数和血钙略有下降。当浓度低至25 mg/L时，二氧化氯会导致身体和器官重量的剂量相关下降，但其最显著的毒性作用是在所有浓度下诱发鼻病变。 包括39个参考文献和表格。

In separate subchronic toxicity studies, male and female SpragueDawley rats received various dosages of chlorine, monochloramine, or chlorine dioxide in their drinking water for 90 consecutive days. None of the disinfectants caused premature death at any of the concentrations used. The highest dose of chlorine tested (250 mg/L) was concluded to be a no observable adverse effect level. At 200 mg/L (the lowest observable adverse effect level), monochloramine produced decreased body and organ weights in both sexes and a small decrease in red blood cell count and serum calcium in males. Chlorine dioxide produced dosage-related decreases in body and organ weight at concentrations as low as 25 mg/L, but its most significant toxic effect was the induction, at all concentrations, of nasal lesions. Includes 39 references, tables.