The U.S. Environmental Protection Agency is in the process of assessing the performance and potential health risks of several drinking water disinfectants and their by-products. To provide field data for this assessment and to more thoroughly understand the interactions of disinfection and disinfection by-product control regarding the advantages and disadvantages of a selected direction, studies were done at two drinking water utilities. This paper will discuss some of the results from these studies which consisted of a pilot plant evaluation at Jefferson Parish, Louisiana and bench-scale evaluations at Evansville, Indiana. Chlorine, chloramine, chlorine dioxide, and ozone were studied in Louisiana; the major objectives of this study were to evaluate the microbiological effectiveness of the disinfectants, the control of halogenated byproducts, and potential health effects associated with the use of these disinfectants. Chlorine dioxide was compared to chlorine in the Indiana study.