Several incidents with quick release cylinder valves that are used on some firefighting system gas cylinders have been reported. In one incident, a worker died and in other cases workers suffered bone fractures (shinbone, hand).In all cases, the cause of the incidents was either the unexpected or intentional opening of the valve fitted to the gas cylinder during handling, filling, or venting of the cylinder. The consequences were that the cylinders went out of control after the valve opened.This publication provides guidelines for the handling of gas cylinders during filling, storage, discharge, maintenance, periodic inspection, and transport equipped with quick release cylinder valves used in firefighting systems.Quick release cylinder valves are used on cylinders typically containing carbon dioxide, nitrogen, or gas mixtures in firefighting systems.