Points out that HVAC operation can play a crucial role in controlling indoor radon concentrations. Both the introduction of fresh air and the pressurisation of an indoor space have been considered as a means of reducing indoor radon concentration levels. Using an in-house computer model, examines the impact of configurational and operational parameters of a building and HVAC system on indoor radon concentrations in a large building. Describes the three-phase approach which was followed. From the results concludes that building ventilation rate and the outdoor air to exhaust air ratio are significant parameters that affect indoor radon concentration.KEYWORDS: year 1996, Radon, buildings, indoor, air quality, calculating, heating, ventilation, air conditioning, operations