Radiological protection - Performance criteria for service laboratories performing biological dosimetry by cytogenetics (ISO 19238:2014)
放射防护 - 通过细胞遗传学进行生物剂量测定的服务实验室的性能标准(ISO 19238:2014)
发布日期:
2017-10-18
实施日期:
2017-10-18
ISO 19238:2014提供质量保证和质量控制标准,性能评估以及细胞遗传学服务实验室对生物剂量学的认证。
ISO 19238:2014地址
a)个人信息的保密性,对于客户和服务实验室,
b)实验室安全要求,
c)校准源和校准剂量范围可用于建立有助于从染色体畸变频率和最小可分辨剂量进行剂量估计的参考剂量效应曲线,
d)用于生物剂量测定的不稳定染色体畸变的评分程序,
e)将测量的像差频率转换为吸收剂量的估计的标准,
f)报告结果,
g)质量保证和质量控制,
h)包含客户样本说明的资料性附录,样本问卷,报告样本,通过最大似然法拟合低剂量 - 反应曲线,计算剂量估计误差,疑似暴露于低位的比例比法剂量和用于记录像差的样品数据表
ISO 19238:2014 provides criteria for quality assurance and quality control, evaluation of the performance, and the accreditation of biological dosimetry by cytogenetic service laboratories.
ISO 19238:2014 addresses
a) the confidentiality of personal information, for the customer and the service laboratory,
b) the laboratory safety requirements,
c) the calibration sources and calibration dose ranges useful for establishing the reference dose-effect curves that contribute to the dose estimation from chromosome aberration frequency and the minimum resolvable doses,
d) the scoring procedure for unstable chromosome aberrations used for biological dosimetry,
e) the criteria for converting a measured aberration frequency into an estimate of absorbed dose,
f) the reporting of results,
g) the quality assurance and quality control,
h) informative annexes containing sample instructions for customer, sample questionnaire, sample of report, fitting of the low dose-response curve by the method of maximum likelihood and calculating the error of dose estimate, odds ratio method for cases of suspected exposure to a low dose, and sample data sheet for recording aberrations.