The US Environmental Protection Agency has proposed regulations that may impose stricter disinfection requirements while limiting the allowable concentrations of disinfection byproducts (DBPs). This dilemma forces utilities to consider treatment techniques such as ozonation, enhanced coagulation and biological filtration. The optimum conditions for these processes may contradict other treatment objectives such as the complete oxidation/removal of iron and manganese. The New Jersey-American Water Company's Delaware River Regional Water Treatment Plant is a 30 million gallon per day ozone treatment facility that went on-line in April 1996. As a state-of-the-art facility, its treatment scheme consists of ozonation, enhanced coagulation and biological filtration. During the early months of operation, treatment was optimized for particle and turbidity removal and total organic carbon (TOC) removal while maintaining adequate disinfection. While it was clear that this produced very good quality, biologically stable water, low levels of manganese oxide were detected in the clearwell, plant effluent and at several points in the distribution system. The main objective of this study was to optimize treatment conditions for iron and manganese removal without a detrimental effect on DBP precursor removal and biological filtration.