为了更好地了解一氯胺的作用方式，研究了它对大肠杆菌B结构和生理完整性的影响。消毒剂没有严重破坏细菌的细胞膜或影响核酸功能。在通常用于消毒的浓度下，观察到典型的蛋白质相关生物活性受到抑制，例如细菌运输、呼吸和底物脱氢。不同生物活性的杀灭率和抑制率的差异表明，失活曲线上肩部的形成是由于细菌中许多敏感部位的反应，其程度决定了该生物体是否仍然可以恢复。包括47个参考文献、表格、图表。

To better understand the mode of action of monochloramine, its effect on the structural and physiological integrity of Escherichia coli B was studied. The disinfectant did not severely damage the cell envelope of the bacterium or affect nucleic acid function. Inhibition of typical protein-associated biological activities, e.g., bacterial transport, respiration, and substrate dehydrogenation, were observed at concentrations normally used for disinfection. Differences in rates of kill and inhibition of various biological activities suggest that the shoulder formation on inactivation curves was due to reactions at many sensitive sites in the bacterium, the extent of which determined whether the organism remained recoverable. Includes 47 references, table, figures.