ISO\/TS 19590:2017规定了一种检测水悬浮液中纳米颗粒的方法，并以时间分辨模式使用电感耦合等离子体质谱（ICP-MS）测定单个纳米颗粒的质量和离子浓度，表征颗粒数量和质量浓度以及基于数量的尺寸分布。该方法适用于无机纳米颗粒（如金属、金属氧化物如Au、Ag、TiO2、BoV4等）的测定，其尺寸范围为10 nm至100 nm（和较大颗粒，高达1～000 nm至2 000 nm）。除了已知的化学成分和密度之外，还可以确定氧化物（例如硫化物等）、金属复合物或具有金属芯的包覆颗粒的金属化合物。可在水悬浮液中测定的颗粒数浓度范围从106个颗粒\/ L到109个颗粒\/ L，其对应于在约1 ng\/L至1个000 ng\/L（60 nm Au颗粒）的范围内的质量浓度。实际数量取决于所用质谱仪的类型和所分析的纳米粒子的类型。除了颗粒浓度外，还可以测定悬浮液中的离子浓度。检测限与标准的电感耦合等离子体质谱测量值相当。注意，粒径小于spICP-MS方法的粒径检测限的纳米颗粒可以被量化为离子。本文提出的方法不适用于有机或碳基纳米颗粒的检测和表征，如包埋体、富勒烯和碳纳米管（CNT）。此外，它不适用于除碳以外的元素以及难以用电感耦合等离子体质谱法测定的元素。参考文献[5]概述了可检测的元素以及用spICP-MS法测定的最小粒径。

ISO/TS 19590:2017 specifies a method for the detection of nanoparticles in aqueous suspensions and characterization of the particle number and particle mass concentration and the number-based size distribution using ICP-MS in a time-resolved mode to determine the mass of individual nanoparticles and ionic concentrations. The method is applicable for the determination of the size of inorganic nanoparticles (e.g. metal and metal oxides like Au, Ag, TiO2, BVO4, etc.), with size ranges of 10 nm to 100 nm (and larger particles up to 1 000 nm to 2 000 nm) in aqueous suspensions. Metal compounds other than oxides (e.g. sulfides, etc.), metal composites or coated particles with a metal core can be determined if the chemical composition and density are known. Particle number concentrations that can be determined in aqueous suspensions range from 106 particles/L to 109 particles/L which corresponds to mass concentrations in the range of approximately 1 ng/L to 1 000 ng/L (for 60 nm Au particles). Actual numbers depend on the type of mass spectrometer used and the type of nanoparticle analysed. In addition to the particle concentrations, ionic concentrations in the suspension can also be determined. Limits of detection are comparable with standard ICP-MS measurements. Note that nanoparticles with sizes smaller than the particle size detection limit of the spICP-MS method may be quantified as ionic. The method proposed in this document is not applicable for the detection and characterization of organic or carbon-based nanoparticles like encapsulates, fullerenes and carbon nanotubes (CNT). In addition, it is not applicable for elements other than carbon and that are difficult to determine with ICP-MS. Reference [5] gives an overview of elements that can be detected and the minimum particle sizes that can be determined with spICP-MS.