在动物体内发现了可以改变动物内分泌系统的化合物 人类活动导致世界各地的水资源供应。这些 这种物质被称为内分泌干扰物（EDC），并已被广泛使用 与对人类和野生动物的各种不良影响有关，包括激素依赖性癌症、生殖道疾病和死亡率降低 生殖健康。药物化合物及其代谢产物已被广泛研究 统称为药物活性化合物（PHAC）。许多PHAC 现已在地表水中检测到，其中一些已在地表水中检测到 喝完了水。水源水中EDC和PHAC的检测具有重要意义 由于这些化合物在低温下具有已知的生理反应，因此备受关注 浓度。个人护理产品（PCPs）创造了另一类新兴市场 在地表和地下水中检测到的污染物。一些PHAC PCP（PPP）具有高度持久性，可以作为EDC发挥作用。多数 与传统污染物相比，EDC和PPCP的极性更强，例如 多氯联苯，还有一些含有酸性或碱性部分。这些 特性，加上痕量，为去除过程和分析检测带来了独特的挑战。 一般有三种方法 用于监测EDC和PPCP的去除:直接测量目标 通过分析仪器测定化合物；生物分析；间接的 化合物类别的化学测量（例如，有机碘）。这些 本文讨论了一些方法，重点讨论了直接测量的分析方法 测量。作为AWWA研究基金项目评估EDCS去除的一部分 在水处理过程中，已经开发出一种使用PPCP的方法 自动固相萃取和气液串联质谱 光谱仪检测。这种方法允许痕量识别和分析 在不同类型的样品中对一组EDC和PPCP化合物进行定量 水 包括27个参考文献、表格和图表。

Compounds that can alter the endocrine system of animals have been detected in water supplies around the world as the result of human activities. These substances are known as endocrine-disrupting compounds (EDCs) and have been linked to a variety of adverse effects in both humans and wildlife including hormone-dependent cancers, reproductive tract disorders, and reduction in reproductive fitness. Pharmaceutical compounds and their metabolites have been collectively termed pharmaceutically active compounds (PhACs). Many PhACs have now been detected in surface water, a few of which have been detected in finished drinking water. The detection of EDCs and PhACs in source water is of great concern since these compounds have known physiological responses at low concentrations. Personal care products (PCPs) create another class of emerging contaminants that have been detected in surface and groundwater. Some PhACs and PCPs (PPCPs) are highly persistent and can function as EDCs. The majority of EDCs and PPCPs are more polar than traditional contaminants, such as polychlorinated biphenyls, and several have acidic or basic moieties. These properties, coupled with trace quantities, create unique challenges for both removal processes and analytical detection. There are three general approaches for monitoring the removal of EDCs and PPCPs: direct measurement of target compounds via analytical instrumentation; biological assays; and, indirect chemical measurements of compounds classes (e.g., organic iodine). These approaches are discussed in this paper with an emphasis on analytical methods for direct measurements. As part of an AWWA Research Foundation project to assess the removal of EDCs and PPCPs during water treatment, a method has been developed which uses automated solid-phase extraction and both gas and liquid tandem mass spectrometer detection. This method permits trace level identification and quantitation of a broad group of EDC and PPCP compounds in various types of water. Includes 27 references, tables, figures.