Performance assessment of full-scale ozonation systems for reduction ofpathogens in drinking water relies on engineering analysis and successful scale-up. The objective of this work was to model the inactivation of Cryptosporidium parvum oocysts in a small-scale experimental ozone contactor using reaction engineering principles and to compare model predictions to inactivation measured in challenge experiments. The experimental system was comprised of a static mixer and short bubble column for rapid ozone dissolution and a reactive flow segment, in the form of a long pipe, for dissolved ozone contact. Includes 8 references, tables, figures.