卤乙酸（HAAs）是氯化消毒过程中产生的消毒副产物之一 含有天然有机物和溴化物的水。美国环境保护局（USEPA）方法552.1和552.2用于 测定HAA需要繁琐的衍生和多个提取步骤，然后是气体 色谱（GC）、电子捕获检测（ECD）和质谱（MS）。离子 色谱-质谱（IC-MS和IC-MS/MS）提供了一种灵敏和选择性的方法 不需要样品预处理的替代品。 水样直接注入一个容器中 离子色谱仪与三重四极质谱仪耦合。9个哈斯的分离 美国环境保护局提出的方法是在2？250毫米还是1毫米？250mm大容量离子交换 柱使用简单的氢氧化物梯度。 在0.4µg/L和100µg/L的范围内，在一个特定的时间段内，可实现出色的峰值分辨率和线性度 基质含有高达250 mg/L的氯化物和硫酸盐，以及30 mg/L的硝酸盐。使用 13CClH2COOH作为内标，检测限小于0。 每种药物4微克/升 五种受管制的卤乙酸（HAA5）和低于1微克/升的其他四种。不重要 观察到基质效应。在模拟试验中，所有九种HAA的回收率均大于90% 上述浓度的矩阵。

Haloacetic acids (HAAs) are among the disinfection byproducts produced during chlorination of water containing natural organic matter and bromide. U.S. Environmental Protection Agency (USEPA) Methods 552.1 and 552.2 used to determine HAAs require tedious derivatization and multiple extraction steps followed by gas chromatography (GC) with electron capture detection (ECD) and mass spectrometry (MS). Ion chromatography-mass spectrometry (IC-MS and IC-MS/MS) offers a sensitive and selective alternative that does not require sample pretreatment. Water samples are directly injected into an ion chromatograph coupled to a triple quadrupole mass spectrometer. The separation of all 9 HAAs addressed in USEPA methods is achieved on either a 2?250 mm or 1?250 mm high-capacity ion exchange column using simple hydroxide gradients. Excellent peak resolution and linearity are achieved between 0.4 µg/L and 100 µg/L in a matrix containing up to 250 mg/L each of chloride and sulfate and 30 mg/L of nitrate. Using 13CClH2COOH as an internal standard, the detection limit is less than 0.4 µg/L for each of the five regulated haloacetic acids (HAA5) and less than 1 µg/L for the other four. No significant matrix effects are observed. Recoveries of all nine HAAs are greater than 90% in a simulated matrix of the above concentrations.