ISO 21013-4:2012规定了低温环境下先导式泄压阀的设计、制造和测试要求，即除了在环境温度到低温温度下运行外，还可在低温流体中运行。仅限于尺寸不超过DN 300的阀门，用于释放单相蒸汽、气体或气体和/或蒸汽混合物。

ISO 21013-4:2012 specifies the requirements for the design, manufacture and testing of pilot operated pressure relief valves for cryogenic service, i.e. for operation with cryogenic fluids in addition to operation at temperatures from ambient to cryogenic. It is restricted to valves not exceeding a size of DN 300 designed to relieve single phase vapours, gases, or mixtures of gases and/or vapours.