PDA第69号技术报告（TR 69）药物生产操作中的生物负载和生物膜管理介绍了当前对药物生产系统中生物负载的原因和控制策略的科学理解，特别强调了流体处理系统中的生物膜。它包括制药和生物制药的制造过程，但不包括最终的无菌和终端灭菌填充完成操作。

PDA Technical Report No. 69, (TR 69) Bioburden and Biofilm Management in Pharmaceutical Manufacturing Operations presents the current scientific understanding of the causes of and control strategies for bioburden in pharmaceutical production systems, with a special emphasis on biofilms in fluid-handling systems. It encompasses pharmaceutical and biopharmaceutical manufacturing processes, but does not include the final aseptic and terminal sterilization fill-finish operations.