这篇文章主张修改风险管理 评估溴酸盐以反映系统前状态 低剂量时通常不考虑的化学反应 根据高剂量毒理学计算风险 数据因为高酸度和 还原剂的存在，系统前 溴酸盐的分解可以从 胃，这应该有助于降低- 预期的靶器官剂量。在这个 溴酸盐分解动力学研究 模拟胃液/胃液 研究以确定环境污染的风险 溴酸盐的相关接触。 目前的工作是一个过程的第一步 作者正在进行的一系列研究 为了更好地估计假设 饮酒对人类的低剂量风险 摄入水分，从而获得更多 适当的最大污染物水平 （MCLs）。作者认为，额外的 动力学和代谢研究将 证明人类摄入的风险 饮用水中的化合物含量较少 比最初相信的要多 更科学的MCL和MCL目标 基于。包括29个参考文献和表格。

This article advocates for a revised risk assessment for bromate to reflect presystemic chemistry not usually considered when low-dose risks are calculated from high-dose toxicology data. Because of high acidity and the presence of reducing agents, presystemic decomposition of bromate can begin in the stomach, which should contribute to lower-than- expected doses to target organs. In this research, bromate decomposition kinetics with simulated stomach/gastric juice were studied to determine the risk of environmentally relevant exposure to bromate. The current work is the first step in a series of studies that the authors are conducting to better estimate the hypothetical low-dose risks to humans from drinking water ingestion and thus arrive at more appropriate maximum contaminant levels (MCLs). It is the authors' belief that additional kinetics and metabolism research will demonstrate that the human risk from ingestion of compounds in drinking water is less than originally believed and will lead to MCLs and MCL goals that are more scientifically based.Includes 29 references, tables.