ISO 16604:2004描述了一种实验室试验方法，用于测量防护服所用材料对血源性病原体渗透的耐受性。本试验方法在连续液体接触条件下使用替代微生物。防护服“合格/不合格”的确定基于使用ISO 13994测试设备在特定静水压力下检测病毒渗透。 该试验方法在测试具有厚内衬的防护服材料时并不总是有效的，内衬容易吸收挑战性液体。 该测试方法涉及敏感的分析程序。 由于完成本试验方法所需的时间较长，它可能不适合用作材料或防护服质量控制或保证程序。

ISO 16604:2004 describes a laboratory test method for measuring the resistance of materials used in protective clothing to penetration by blood-borne pathogens. This test method uses a surrogate microbe under conditions of continuous liquid contact. Protective clothing "pass/fail" determinations are based on the detection of viral penetration at a specific hydrostatic pressure using the ISO 13994 test apparatus. This test method is not always effective in testing protective clothing materials having thick, inner liners which readily absorbs the challenge fluid. This test method involves a sensitive assay procedure. Because of the length of time required to complete this test method, it might not be suitable for use as a material or protective clothing quality control or assurance procedure.