有200多份关于密封空调建筑的健康危害评估报告可供查阅，这些报告是由认为其建筑对其健康有害的居住者提出的。大多数评估由联邦或州卫生部门进行，一些由私人研究机构进行。几乎无一例外，这些建筑都是现代化的、密封的、机械通风和空调的，通常被认为是节能的。在大多数情况下，没有发现与投诉和疾病有关的具体原因或因素。 许多报告认为“建筑疾病”与新鲜空气通风不足有关。开发了一个基于计算机的建筑信息系统，以提取有关内部环境测量、疾病特征和居住者历史的相关信息，以及可获得文件的建筑的建筑和通风条件的相关特征。研究人员探讨了建筑物疾病症状是包括烟草烟雾在内的污染物水平升高的结果的可能性。 在发生严重建筑疾病暴发的建筑物中记录的污染物平均值不超过公认的职业或行业标准认为的有害水平。在禁止吸烟的场所和不禁止吸烟的场所之间，未发现污染物水平或症状有实质性差异。建筑物疾病症状可能不是由任何特定的室内污染源引起的，而是由过滤系统的有效性和外部空气通风量引起的，这些通风量降低了密封建筑物内的整体污染水平，这些建筑物利用机械方式提供通风。 引用:ASHRAE Transactions，1983年，第89卷，第1部分。2a，华盛顿特区。

Over 200 reports of health hazard evaluations are available of sealed, air-conditioned buildings, requested by occupants who believed their buildings to be hazardous to their health. Most evaluations were undertaken by federal or state health departments, and some by private research organizations.Almost without exception, the buildings were modern, sealed, and mechanically ventilated and air-conditioned, and very often considered energy-efficient. In most instances, no specific cause or agent was found to be associated with complaints and illnesses. Many reports considered “building illness” to be associated with inadequate fresh air ventilation.A computer-based building information system was developed to extract relevant information about the internal environment measurements, disease characteristics and history of occupants, as well as relevant features of the architecture and ventilation conditions of buildings for which documentation was available. The possibility was explored that building illness symptoms were a result of elevated levels of pollutants, including tobacco smoke. The average value of pollutants recorded in buildings in which there were severe outbreaks of building illness do not exceed levels deemed to be hazardous by accepted occupational or industrial standards. No substantial differences in pollutant levels or symptoms were found between premises in which smoking was prohibited and premises where it was not.Building illness symptoms may not be so much caused by any specific source of indoor pollution as they are by the effectiveness of the filtration system and the amount of outside air ventilation reducing the overall level of pollution contained within sealed buildings that utilize ventilation supplied by mechanical means.