For over 29 years, reclaimed wastewater has been used to supplement storm flows and imported water in replenishing the Central Basin in Los Angeles. Substantial savings have been realized from the use of reclaimed water, and the quantity of reclaimed water now being recharged each year is equivalent to the water needs of a quarter of a million people. There has been absolutely no degradation of the groundwater quality, and the health of those people indirectly ingesting reclaimed water has not been adversely impacted in any detectable way. There is a significant amount of further replenishment that could utilize reclaimed water in Los Angeles and Orange Counties, if certain environmental, engineering, technical and regulatory considerations can be successfully addressed, thereby helping to alleviate the growing water supply problems in Southern California. This paper presents a broad overview of how this use of reclaimed water affects water supply, economics, and water quality, with most emphasis on water quality. The potential exists to use reclaimed water to replenish groundwater in two other areas: the Upper San Gabriel Basin and the Alamitos Seawater Intrusion Barrier.