室内环境中的生物污染是一个主要的健康问题。事实上，室内空气比室外空气对环境的危害更大——室内空气污染物浓度比室外空气高10到100倍（Berry 1992）。此外，个人，尤其是年轻人、老年人或慢性病患者，可能一天中90%的时间都待在室内（Ott 1988）。生物制剂存在感染、有毒或化学接触或过敏性致敏的风险。由环境生物接触诱发的免疫介导疾病包括哮喘、过敏和过敏性肺炎（Weissman和Schuyler 1991）。 这项工作的目标是:1。描述医学和微生物学文献中描述的室内过敏原和生物毒素。2.描述目前用于量化和识别这些过敏原和生物毒素的采样方法。3.评估目前可用于去除相关生物颗粒的过滤技术。

Biological contamination in the indoor environment is a major health concern. In fact, indoor air can be a greater environmental hazard than outdoor air — indoor air pollutant concentrations have been found to be 10 to 100 times higher than the outdoor air (Berry 1992). In addition, individuals, particularly the very young, old, or chronically ill, may spend as much as 90% of their day indoors (Ott 1988). Biological agents present risks of infection, toxic or chemical exposures, or allergic sensitization. Immunologically mediated diseases induced by environmental biocontaminant exposure include asthma, allergy, and hypersensitivity pneumonitis (Weissman and Schuyler 1991).The objectives of this work are to:1. Characterize the indoor allergens and biological toxins described in the medical and microbiological literature.2. Describe the sampling methods currently used to quantify and identify these allergens and biological toxins.3. Evaluate the filtration techniques currently available for removing the biological particles of concern.