Low Dose Risks from Bromate: The Relationship between Drinking Water Concentrations and the Actual Dose to Susceptible Organs in Rats and Humans, Pre-systemic Decomposition
溴酸盐的低剂量风险:饮用水浓度与大鼠和人类易感器官的实际剂量之间的关系 系统前分解
This powerpoint presentation's research strategy was: to develop Physiologically Based
Pharmacokinetic Model to quantify organ dose
from ingestion and toxic responses at low dose; and,
a mechanism of toxic response at low doses.
This leads to:
re-examination of basis for MCLG; and,
revision of risk assessment at low doses. Topics covered include: Pre-systemic Decomposition; the importance of Bromate in Drinking Water
to Water Suppliers; Bromate Health Risk Summary; Critical Risk Assessment Issues; Critical Risk Assessment Issues; Why Risk Assessment Matters; Previous Research; Bromate Chemistry and Kinetics; Bromate Research Program Overview; Model of Bromate
Toxicokinetics; Transport and Decomposition in vivo; Where are we now-summary; and, Current Study-April 2007 to January 2009.