在用于生产饮用水的地表水中存在非法药物，以及 已在饮用水处理厂（DWTP）对成品水进行了评估。研究 这些化合物在向该污水处理厂提供原水的流域中的出现已被证实 也已经完成了。该分析程序基于超临界流体分析仪对非法药物的分析 高效液相色谱-串联质谱联用（UPLC-ESI-MS/MS） 通过固相萃取（SPE）进行富集步骤后。在地表水中可卡因， 苯甲酰高尼（可卡因代谢物）、安非他明、甲基苯丙胺、摇头丸和 丙二醛的平均浓度在4纳克/升至350纳克/升之间，而 可待因的浓度高达76纳克/升；EDDP（美沙酮的代谢物）为31纳克/升； 12纳克/升 在摄入DWTP时，监测吗啡和美沙酮的浓度分别为9 ng/L和9 ng/L。 研究了饮用水处理过程中这些化合物的消除情况。可卡因、安非他明类兴奋剂、可待因和吗啡均被禁用 在饮用过程中完全去除。美沙酮、EDDP和苯甲酰氯胍 分别减少了91%、87%和90%，是唯一持续存在的化合物 通过治疗。 一项对西班牙处理过的水域的调查表明，有几种非法药物和代谢物被发现 在低纳克/升水平下出现。包括18个参考文献和表格。

The presence of illicit drugs in surface waters used for drinking water production and in finished water has been evaluated in a drinking water treatment plant (DWTP). A study of the occurrence of these compounds in the river basin which provides raw water to this DWTP has also been done. The analytical procedure was based on the analysis of illicit drugs by ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC-ESI-MS/MS) after an enrichment step performed by solid-phase extraction (SPE). In surface waters, cocaine, benzoylecgonine (cocaine metabolite), amphetamine, methamphetamine, MDMA (ecstasy) and MDA were detected at mean concentrations ranging from 4 ng/L to 350 ng/L, whereas concentrations up to 76 ng/L for codeine; 31 ng/L for EDDP (metabolite of methadone); 12 ng/L for morphine and 9 ng/L for methadone were monitored at the intake of the DWTP. The elimination of these compounds during drinking water treatment was investigated. Cocaine, amphetamine type stimulants, codeine and morphine were completely removed during the potabilization process. Methadone, EDDP and benzoylecgonine with reductions of 91%, 87% and 90%, respectively were the sole compounds that persisted through treatment. A survey of Spanish treated waters suggests that several illicit drugs and metabolites are present at low ng/L levels. Includes 18 references, tables.