最近的几份报告记录了饮用水中存在抗生素 来源，来自市政污水的废物流处理不彻底的结果 资源和牲畜经营。高锰酸钾（KMnO₄）是 被许多公用事业公司用于解决一系列问题（如溶解锰、T&O），但很少 已知KMnO₄对氧化抗生素的有效性或治疗效果 关于处理过的水的抗生素效力。这篇文章首次在网上报道 常见抗生素（甲氧苄啶、林可霉素、环丙沙星、， 磺胺甲恶唑、磺胺甲恶唑和金霉素）与KMnO₄。动力学研究 证明KMnO₄是一种选择性氧化剂，表现出明显的二级速率 目标抗生素在pH值为7时的常数范围为<0.03至110 M^-1s^-1。 反应速率 高度依赖于pH值，测量的动力学趋势可以通过考虑 目标抗生素的酸碱形态变化。动力学模型的预测也一致 与饮用水公用事业水源中抗生素处理的测量结果密切相关 可变成分。生物测定实验表明，氧化产物和中间产物 与母体药物相比，其抗菌活性可忽略不计。包括18个参考文献、表格、图表。

Several recent reports have documented the presence of antibiotics in drinking water sources, the result of incomplete treatment of waste streams originating from municipal sources and livestock operations. Potassium permanganate (KMnO₄) is used by a number of utilities to address a range of issues (e.g., dissolved Mn, T&O), but little is known about the effectiveness of KMnO₄ for oxidizing antibiotics or the effect of treatment on antibiotic potency of the treated water. This contribution reports for the first time on the treatment of commonly detected antibiotics (trimethoprim, lincomysin, ciprofloxacin, sulfamethoxazole, sulfamethizole, and chlortetracycline) with KMnO₄. Kinetic studies demonstrate that KMnO₄ is a selective oxidant, exhibiting apparent second-order rate constants with the target antibiotics at pH 7 ranging from <0.03 to 110 M^-1 s^-1. Reaction rates are highly dependent on pH, and measured kinetic trends can be modeled by accounting for changes in acid/base speciation of the target antibiotics. Kinetic model predictions also agree closely with measurements of antibiotic treatment in drinking water utility source waters of variable composition. Bioassay experiments show that oxidation products and intermediates possess negligible antibacterial activity in comparison with the parent drugs. Includes 18 references, tables, figures.