NISP适用于所有行政部门和机构，以及位于美国及其领土内的所有经批准的承包商设施。本手册适用于并应由承包商使用，以保护在合同、许可和授予过程的所有阶段（包括投标、谈判、授予、履行和终止）发布的机密信息。它还适用于未根据合同、许可证、证书或授权发布的机密信息，以及向承包商提供的出于国家安全利益需要保护的外国政府信息。本手册执行适用的联邦法规、E.O.s、国家指令、国际条约和某些政府间协议。承包商对本手册的变更应在发布变更之日起6个月内生效，但与我方相关的变更除外- 本手册第4章和第10章第8节中的英国和美国-澳大利亚（AUS）条约要求，必须立即实施。本手册不包含特殊核材料的保护要求。

The NISP applies to all Executive Branch Departments and Agencies and to all cleared contractor facilities located within the United States and its territories.This Manual applies to and shall be used by contractors to safeguard classified information released during all phases of the contracting, licensing, and grant process, including bidding, negotiation, award, performance, and termination. It also applies to classified information not released under a contract, license, certificate or grant, and to foreign government information furnished to contractors that requires protection in the interest of national security. This Manual implements applicable Federal statutes, E.O.s, national directives, international treaties, and certain government-to-government agreements.Implementation of changes to this Manual by contractors shall be effected no later than 6 months from the date of the published change, with the exception of changes related to US-UK and US-Australia (AUS) Treaty requirements, in Chapters 4 and 10, Section 8 of this Manual, which must be implemented immediately.This Manual does not contain protection requirements for Special Nuclear Material.