本研究的主要目的是开发一种正负开关模式ESI/LC/MS方法，用于经济高效地筛选和监测水源和饮用水中的非离子表面活性剂和酚类内分泌干扰物（EDC）。这些研究包括固相萃取（SPE）样品制备、分离和检测条件的优化。将研究方法灵敏度、准确度和精密度以及基质效应。初步结果表明，这些分析物可以通过梯度乙腈/水流动相在反相柱上分离，并通过ESI/MS进行检测。包括29篇参考文献、表和图。

The major aim of this research is to develop a positive and negative switching mode ESI/LC/MS method for the cost-effective screening and monitoring of nonionic surfactants and phenolic endocrine disruptors (EDCs) in source and drinking waters. The studies include the optimization of solid phase extraction (SPE) sample preparation, separation, and detection conditions. Method sensitivity, accuracy and precision as well as matrix effects will be studied. The preliminary results indicate that these analytes can be separated on a reverse phase column by a gradient acetonitrile/water mobile phase and detected by ESI/MS. Includes 29 references, table, figures.