虽然二氧化氯和臭氧是很好的消毒剂，但它们的反应产物对健康的影响尚不完全清楚。二氧化氯和臭氧氧化产生的氧化有机化合物产生的亚氯酸盐离子可能有毒。除非这些物质得到鉴定并证明其安全性，否则二氧化氯或臭氧都不应替代水中的氯消毒。包括18篇参考文献。

Although chlorine dioxide and ozone are good disinfection agents, the health effects of their reaction products are not completely understood. The chlorite ion produced by chlorine dioxide and oxidized organic compounds resulting from ozonation may be toxic. Until or unless these substances are identified and their safety demonstrated, neither chlorine dioxide or ozone should be substituted for chlorine in water disinfection. Includes 18 references.