指南6确定了产品开发和系统设计工程师、ASHRAE标准以及在制冷或空调设备中成功应用制冷剂的适当规范可能需要的制冷剂数据类型。它还为制冷剂供应商和研究人员提供了测量方法、以前的研究以及各种制冷剂特性所需的精度水平的示例。2015版指南6包括2008年在美国未商业化使用的新制冷剂产品系列:碳氢化合物、氢氟烃和醚。新型低可燃性等级2L制冷剂和混合物的商业开发引入了ASHRAE标准34和15以及各种应用的风险评估所需的额外（可选）属性信息，如燃烧速度、自燃温度、最小点火能量、热表面点火温度、，以及更严格的热稳定性和水解稳定性。 系统化学、制冷剂反应性和混合分馏测试将更详细地介绍，以反映最近的技术发展。指南6-2008中未涵盖CO2次临界和跨临界循环应用，但由于对“天然制冷剂”的新兴趣以及对全球变暖的担忧，本版中涵盖了这些应用。引文:ASHRAE指南

Guideline 6 identifies the types of refrigerant data that may be required by product development and system design engineers, ASHRAE standards, and appropriate codes to successfully apply a refrigerant in refrigeration or air-conditioning equipment. It also provides refrigerant suppliers and researchers with examples of measurement methods, previous research, and desired accuracy levels for various refrigerant properties.The 2015 edition of Guideline 6 includes new refrigerant product families that were not commercially used in the United States in 2008: hydrocarbons, hydrofluoro-olefins, and ethers. The commercial development of a new lower flammability Class 2L of refrigerants and blends introduces additional (optional) property information needed in ASHRAE Standards 34 and 15 and in risk assessments for various applications, such as burning velocity, autoignition temperature, minimum ignition energy, hot surface ignition temperature, and more stringent thermal and hydrolytic stability properties. System chemistry, refrigerant reactivity, and blend fractionation testing are covered in greater detail to reflect recent technology developments. CO2subcritical and transcritical cycle applications were not covered in Guideline 6-2008, but they are covered in this edition due to renewed interest in "natural refrigerants" and concerns for global warming.