生物危害安全是实验室环境中一个公认的问题，在实验室环境中，生物制剂是常规处理的。这些环境包括微生物实验室、病毒学和病理学实验室、尸检室和实验动物宿舍。这些实验室可能与临床分析、生物研究或生物材料的商业生产有关。“生物危害”或有害生物制剂可定义为对人类、其他动物或植物的健康或福祉有害的任何物质。这包括活微生物、病毒、致癌物和有毒物质。从时间和联邦支出的影响来看，洁净室设备的发展与生物危害安全的发展密切相关。20世纪50年代末，灰尘控制的roorns开始在工业上用于组装真空管和低电阻微型继电器。这些roorns通常被称为“白色房间”，以强调清洁度要求和特殊的皮棉- 工人们穿的免费衣服。工业洁净室和生物实验室的学科也有很多共同之处。两者都与污染控制有关。在涉及产品和人员的任何污染控制系统中，必须考虑三个因素:环境控制、人员程序和过程工程。这些因素已在洁净室文献中反复讨论过。关于实验室生物危害安全，可确定以下三个考虑因素:1。控制设备。一级和二级微生物屏障设备的设计和使用必须防止气溶胶生物危害在实验室环境内或外部环境中传播。该安全壳设备因素涉及对洁净室空气过滤和空气控制原理的理解和正确应用。必须先控制环境，然后才能控制污染接触转移的其他因素。 2.安全程序。必须制定经过仔细考虑和控制的程序，以防止生物危害剂与实验室工作人员之间的直接接触。这包括正确使用移液管、针头和注射器、手套和个人卫生程序。3.工艺设备。为了确保离心机等设备在使用过程中不会受到污染，必须小心控制。应对此类设备进行分析，以便于去污或消毒，消除飞溅或气溶胶的产生，并减少工人接触潜在接触污染的机会。引文:俄亥俄州辛辛那提ASHRAE学报第87卷第2部分研讨会

Biohazard safety is a recognized concern in laboratory environments where biological agents are routinely handled. Such environments include microbiological laboratories, virology and pathology laboratories, autopsy rooms and laboratory animal quarters. These laboratories may be associated with clinical analysis, biological research, or the commercial production of biological materials.A "biohazard" or hazardous biological agent may be defined as any substance which is harmful to the health or well-being of man, other animals or plants. This includes viable microorganisms, viruses, carcinogens, and toxic substances.The development of clean room equipment closely parallels the development of biohazard safety from the standpoint of time and the influence of federal spending. Dust controlled roorns began to be used in industry for assembling vacuum tubes and low resistance miniature relays in the late 1950's. These roorns were often called "white rooms" to emphasize the cleanliness requirements and special lint-free garments which were worn by the workers.Much has been shared by the disciplines of industrial clean rooms and biological laboratories. Both are concerned with contamination control. In any contamination control system involving a product and people, there are three factors which must be considered: environmental control, personnel procedures, and process engineering. These factors have been discussed repeatedly in the clean room literature. In relation to laboratory biohazard safety these three considerations can be identified as follows:1. Containment Equipment. Primary and secondary microbiological barrier equipment must be designed and used to prevent the spread of the aerosolized biohazard within the laboratory environment or to the outside environment. This containment equipment factor involves the understanding and proper application of clean room principles of air filtration and air control. The environment must be controlled before it is possible to control the other factors of contact transfer of contamination.2. Safety Procedures. Carefully thought out and controlled procedures must be developed to prevent the direct contact between the biohazard agent and the laboratory worker. This involves the correct use of pipets, needles and syringes, gloves, and personnel hygiene procedures.3. Process Equipment. Process equipment such as sterilizers, centrifuges, blenders and incubators must be carefully controlled to assure that contamination does not occur during their use. Such equipment should be analyzed for ease of decontamination or sterilization, elimination of splashing or aerosol production, and reduction of exposure of the worker to potential contact contamination.