BS ISO 11843-5:2008+A1:2017 is concerned with calibration functions that are either linear or non-linear.It specifies basic methods toconstruct a precision profile for the response variable, namely a description of the standard deviation (SD) or coefficient of variation (CV) of the response variable as a function of the net state variable,transform this precision profile into a precision profile for the net state variable in conjunction with the calibration function, anduse the latter precision profile to estimate the critical value and minimum detectable value of the net state variable.The methods described in this part of ISO 11843 are useful for checking the detection of a certain substance by various types of measurement equipment to which ISO 11843?2 cannot be applied. Included are assays of persistent organic pollutants (POPs) in the environment, such as dioxins, pesticides and hormone-like chemicals, by competitive ELISA (enzyme-linked immunosorbent assay), and tests of bacterial endotoxins that induce hyperthermia in humans.Cross References:ISO 3534-1:2006ISO 3534-3:2013 ED3ISO 3534-2:2006 Ed 2 (R10)ISO 5725-1:1994ISO 11843-1:1997ISO 11843-2:2000 (R11)ISO 3534-3:1999Incorporates the following:Amendment, November 2017