The pharmaceutical industry has requirements for its clean rooms which are alien in other facilities. The F.D.A. (Food and Drug Administration) and its own Q.C. (Quality Control) Department impose design criteria which make the facility a highly specialized space. Traditional air flow rates must be disregarded. Sufficient air to satisfy the cooling load is inadequate for other purposes, while typical clean room air quantities can be considerably reduced to attain the desired effect.This paper suggests economically feasible solutions for the design of a pharmaceutical clean room.