已经建立了许多数学模型 在过去的一个世纪里代表 暴露微生物种群的剂量-反应曲线 去消毒。从小鸡沃森开始 在Gard、Hom和 延迟奇克-沃森模型，这些表示 在概念上有共同的基础 微生物和消毒剂之间的相互作用 是一个类似于 正在发生反应的化学物质。 作者回顾了这些模型的发展 并提出了一种基于 微生物种群抗药性的多样性 消毒剂。如果更多的研究证实了它的有效性， 这个假设应该有助于解释这种可变性 可见微生物对特定消毒剂的反应。 更好地理解微生物是如何 灭活将帮助公用事业公司遵守监管规定 并可能导致改进工程设计 满足这些要求的设计。包括23个参考文献、表格和图表。

A number of mathematical models have been developed over the past century to represent the dose-response curve of a microbial population exposed to a disinfectant. Beginning with the Chick-Watson model and continuing through the Gard, Hom, and delayed Chick-Watson models, these representations have in common their foundation on the concept that the interaction between a microorganism and a disinfectant is a kinetic process similar to that between chemicals undergoing a reaction. The author reviews the development of these models and proposes an alternative interpretation based on the diversity of the microbial population in its resistance to a disinfectant. If additional research confirms its validity, this hypothesis should help explain the variability seen in microorganisms' responses to a specific disinfectant. A better understanding of how microorganisms are inactivated will assist utilities in complying with regulatory requirements and may lead to improved engineering designs for meeting those requirements. Includes 23 references, table, figures.